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I read this for work and while the science DNA level detail in the front part is pretty dense, the book really opens up when he writes about the possibility for treating aging as a disease and all the things that currently kill us heart disease, cancers as its symptoms And then the social impacts of society living much, much longer than we currently do I am now operating as if I will live to 100, and we re talking GOOD years, not wasting away So this book has really changed the way I think about aging, which I used to just accept as something inevitable. (((Free Pdf))) ⇲ Lifespan ☂ It S A Seemingly Undeniable Truth That Aging Is Inevitable But What If Everything We Ve Been Taught To Believe About Aging Is Wrong What If We Could Choose Our Lifespan In This Groundbreaking Book, Dr David Sinclair, Leading World Authority On Genetics And Longevity, Reveals A Bold New Theory For Why We Age As He Writes Aging Is A Disease, And That Disease Is Treatable This Book Takes Us To The Frontlines Of Research Many From Dr David Sinclair S Own Lab At Harvard That Demonstrate How We Can Slow Down, Or Even Reverse, Aging The Key Is Activating Newly Discovered Vitality Genes, The Descendants Of An Ancient Genetic Survival Circuit That Is Both The Cause Of Aging And The Key To Reversing It The book consists of 1 a history of aging and longevity related science, 2 a a handwavey survey of some interesting metabolic pathways and genetic epigenetic programming techniques that Prof Sinclair and friends have pursued, 3 philosophical, aesthetic, and moral arguments on why pursuing lifespan extension is good.It s well written and I enjoyed Prof Sinclair s distinctive writing style and purview I learned a bit on what papers and authors I should readdeeply for Parts 1 and 2 , but I was disappointed in the overall depth and lack of systematic, holistic discussion of how the individual research streams came together I thought 3 was finely articulated, but no conceptual new grounds were covered The main thesis that Sinclair builds up is his Information Theory of Aging He s inspired by Claude Shannon s seminal work and the TCP IP protocol, but the analogy is not very well fleshed out and feels like a forced analogy Essentially, Prof Sinclair believes that epigenetic debris accrues on DNA and aging cells lose differentiation Sinclair believes this can be reversed because each cell has a stored copy of youthful epigenetic state that can re programmed towards It s an intriguing idea but he unfortunately doesn t provide much evidence or even a mechanism of how this actually works in practice Recommended for novice longevity enthusiasts, but there s not much new insight for the serious reader unfortunately. Coming from a perspective of someone who studies evidence based nutrition, exercise, and healthy lifestyle factors for over a decade now, this book is a must read.Solving aging is one of the final frontiers for humankind, and the information David has provided here is a big step in the right direction It has the power to bringawareness to solving aging as well as shift strong limiting beliefs that have been deeply rooted in public as well as the scientific community.We ve come very far in research, but sadly the mainstream still hasn t caught up as many of the theories often mentioned have already been invalidated Big thanks to David and his team for putting together all the most up to date longevity research in one place.Having read this book I m evenexcited about future research and grateful to be alive in this time where such research is taken seriously. Highly recommended for anyone wanting to understand the hallmarks of ageing and how to manage them.Understandable and well communicated science underpinning human longevity David wrote it in a way a layman like myself could easily understand The book lays down the existing science Past what we know and moves to where we are now Present what we are learning Then moves through to where we are going future breakthrough science and this is where it starts to get really existing The future looks bright. The authors have written an excellent book on a subject that affects everyone It s not too technical and has personal stories to make you really think about treating aging as a disease It was a very enjoyable read. I love this book so much It has a deep personal connection and justifies its facts Definitely favourite book ever This is quite good A heck of a lot of info packed into this, which essentially covers what might become available in the next 10 40 years, and touches on on the potential impacts on society as a result of people living longer You re not going to learn how to live longer, but you will learn some interesting stuff Recommended for curious minds.I really appreciate the advanced copy for review Within our lifetimes many will be able to live longer than 120 years, while enjoying at age 80 90 the health of 30 40 year olds.Gene therapies that can reverse organ damage, like macular degeneration, and get rid of senescent cells, which increase with age and cause the various illnesses of old age, are already proving to be successful in the lab We will be able to program genes in a way that makes humans immune to most fatal diseases A Chinese doctor has already gene edited a girl who is immune to AIDS One of Sinclair s students has been able to grow nerves connecting the eyes to the brain in mice, and there is confidence among researchers that the same could be done for humans Aging has been reversed in 12month old mice, the equivalent of 60 year old humans treated 12month old mice who ve practically reached ripe old age were able to runthan 3kilometers, which greatly exceeds the running capacity of even young mice over their lifetime Similar effects can be induced in humans using similar enzymes and gene editing technologies in the near term future which Sinclair places at a maximum of 30 years from now.Also, pointers on how to live longer Fasting so you are sort of hungry as frequently as possible, and generally consuming 25% fewer calories than currently recommended for your Body Mass Index is ideal.Exposing yourself to lower temperatures than you re most comfortable at, where your body needs to do some work to keep you warm, triggers the survival circuit and slows down cellular aging and so the process of aging itself.Regular exercise, at an intensity where you can t complete sentences and are short of breath, also slows down aging.Read this interview where Sinclair touches on most of the topics in the book I ve been following David Sinclair s research into aging for many years, and this book is a great summary of his work and that of others, where the field of aging research is headed, and what we can expect Dr Sinclair is and has always been an optimist I m an optimist too, so that s fine by me While he isn t a medical doctor and can t give medical advice, he discusses supplements he takes and lifestyle choices he makes that he feels are helping him and his own family too, including his 80 year old father who has returned to work and is enjoying vibrant good health My own disclaimer, I have been taking an NAD booster for almost five years I do believe it makes a difference At 56, I have farenergy than same aged friends, and I haven t been sick since I started taking it, something Dr Sinclair mentions too Because I have inherited a copy of the APOE4 gene for Alzheimer s, I m always interested in learning about anything I can do exercise or take supplements that will help prevent that gene from turning on Toward the final quarter of the book, Dr Sinclair turns to the ethics of slowing or even preventing aging What would a world look like in which people might start a new career in their seventies, or enjoy spending time with their great great grandchildren, still vital and engaged How would it impact global overpopulation and use of resources These are all important questions, and he presents various scenarios in a balanced way Overall, a fabulous read I m going to get the PDF as well so I can look at the charts and images references recommended by the author as well I do truly feel that we re on the brink of longevity escape velocity, and I couldn t beexcited